IMAGE PROCESSING AND ANALISYS LAB
PRECLIN Project:
Overview
The PRECLIN project is coordinated by the Bucharest
Institute of Oncology (project director m.c. Acad. Prof. dr. h.c dr. Nicolae
MANOLESCU) The partners of the project are the Institute for Comparative Medecine
(team headed by Assoc. Prof. Emilia Balint) and the Image Processing and Analysis Lab LAPI
(team headed by Prof. Dr. Ing. Constantin VERTAN) from the Politehnica University of Bucuresti.
The frequency
of canine oncopathies is larger then that in humans – in human an average of
200 cases to 100000 inhabitants, and in dogs it reaches 17000 cases to 1000000
canides. Starting with this argument is presented a research project as a premiere, based on a new
concept describing on the relation canine cancer – oncosentinel – human cancer.
The dog must be considered the most valuable oncosentinel for cancer disease,
because following the contact with onco-inductor substances in the life
environment, cancer disease is beginning fast, a very useful element for the
humans because in optimum time eco-oncotherapy and eco-oncoprophylaxis measures
in the life environment can be adopted. Literacy shows that:
1. it is a similitude of
anatomic-clinical forms of cancer disease in dogs and in humans. Between the
two species is a superposition concerning the etiology and the epidemiology of
cancer disease, but also of the actual therapy methods or the obtained
therapeutic results.
2. the veterinary clinic pretrial for the human oncology, for every therapeutic method, including the toxicological tests and for the verify of antitumoral action of therapeutic drugs is first done in vitro, the tests continuing in vivo in mice and rats, animals with experimental tumors.
In consequence, the
canine model is proposed as study for the human oncology by testing new drugs
and new anticancer therapeutic schemes on the canine cases, aiming their
introduction in the human trial. In these circumstances it wouldn't be
extrapolated in humans the results obtained in culture cells and experimental
rodents with experimental tumors, but also would be extrapolated the results
obtained in an animal specie with spontaneous tumors (the dog), who develops
anatomic-clinical forms similar with that in human cancers, giving so an
extremely high research level for the clinic pretrial in the canine model.